Estradiol-d5

CAT: 0804-HY-B0141S2-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0141S2-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Estradiol-d5 is deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].
CAS Number
[221093-45-4]
Product Name Alternative
β-Estradiol-d5; 17β-Estradiol-d5; 17β-Oestradiol-d5
UNSPSC
12352005
Hazard Statement
H225, H302+H312+H332, H319
Target
Endogenous Metabolite; Estrogen Receptor/ERR
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology; Cancer
Purity
99.73
Solubility
10 mM in DMSO|Ethanol : 20mg/mL (ultrasonic)
Smiles
C[C@]1(CC2)[C@](CC([2H])([2H])[C@]1([2H])O)([H])[C@@](CCC3=C4[2H])([H])[C@@]2([H])C3=CC([2H])=C4O
Molecular Formula
C18H19D5O2
Molecular Weight
277.41
Precautions
H225, H302+H312+H332, H319
References & Citations
[1]Harburger LL, et al. Dose-dependent effects of post-training estradiol plus progesterone treatment on object memory consolidation and hippocampal extracellular signal-regulated kinase activation in young ovariectomized mice. Neuroscience. 2009;160 (1) :6-12.|[2]Mermelstein PG, et al. Estradiol reduces calcium currents in rat neostriatal neurons via a membrane receptor. J Neurosci. 1996 Jan 15;16 (2) :595-604.|[3]Quanfu Huang, et al. 17β-estradiol Upregulates IL6 Expression Through the ERβ Pathway to Promote Lung Adenocarcinoma Progression. J Exp Clin Cancer Res. 2018 Jul 3;37 (1) :133.|[4]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[5]Woolley CS, et al. Estradiol increases the sensitivity of hippocampal CA1 pyramidal cells to NMDA receptor-mediated synaptic input: correlation with dendritic spine density. J Neurosci. 1997 Mar 1;17 (5) :1848-59.|[6]Woolley CS, et al. Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat. J Neurosci. 1992 Jul;12 (7) :2549-54.|[7]Woolley CS, et al. Roles of estradiol and progesterone in regulation of hippocampal dendritic spine density during the estrous cycle in the rat. J Comp Neurol. 1993 Oct 8;336 (2) :293-306.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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