RUNX1T1 Mouse Monoclonal Antibody [Clone ID: LBI1H1]

• Background:

  This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t (8;21) (q22; q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq]

• Synonyms:

  AML1-MTG8; AML1T1; CBFA2T1; CDR; ETO; MTG8; ZMYND2

• Gene Name:

  RUNX1 partner transcriptional co-repressor 1

• Gene ID:

  862

• UniProt:

  Q06455

• Conjugation:

  Unconjugated

• Related Pathways:

  Acute myeloid leukemia, Pathways in cancer

• Field of Research:

  Acute myeloid leukemia, Pathways in cancer

• Concentration:

  1 mg/ml

• Dilution:

  WB 1:2000, IF 1:100

• Form:

  PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

• Buffer:

  PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

• Function:

  Transcription Factors

• Storage Conditions:

  Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Symbol:

  RUNX1T1

• Overview:

  RUNX1T1 (ETO) mouse monoclonal antibody, clone LBI1H1

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=862

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q06455