RUNX1T1 (NM_175636) Human Recombinant Protein

• Background:

  This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t (8;21) (q22; q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]

• Synonyms:

  AML1-MTG8; AML1T1; CBFA2T1; CDR; ETO; MTG8; ZMYND2

• Gene ID:

  862

• UniProt:

  Q06455, W8FW32

• Accession Number mRNA:

  NM_175636

• Chromosomal Location:

  8q21.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Acute myeloid leukemia, Pathways in cancer

• Field of Research:

  Acute myeloid leukemia, Pathways in cancer

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Transcription Factors

• Molecular Weight:

  63 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  RUNX1T1

• Species:

  Human

• Protein ID:

  NP_783554

• Overview:

  Recombinant protein of human runt-related transcription factor 1; translocated to, 1 (cyclin D-related) (RUNX1T1), transcript variant 4

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/862

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q06455

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_175636

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_783554