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NGF Protein, Mouse, Recombinant

CAT: 0882-PM53249M0-01Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0882-PM53249M0-01Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Nerve growth factor (NGF) is important for the development and maintenance of the sympathetic and sensory nervous systems. NGF protein was identified as a large complex consisting of three non-covalently linked subunits, α, β, and γ, among which, the β subunit, called β-NGF (beta-NGF), was demonstrated to exhibits the growth-stimulating activity of NGF protein. NGFB/beta-NGF gene is a member of the NGF-beta family and encodes a secreted protein that homodimerizes and is incorporated into a larger complex. NGF protein acts via at least two receptors on the surface of cells (TrkA and p75 receptors) to regulate neuronal survival, promote neurite outgrowth, and up-regulate certain neuronal functions such as mediation of pain and inflammation. Also, previous studies indicated that NGF may also have an important role in the regulation of the immune system.
Overview
A DNA sequence encoding the mature form of mouse NGF (NP_001106168.1) (Ser 122-Gly 241) was expressed, with an initial Met at the C-terminus.
Synonyms
Ngfb Protein, Mouse
Gene Name
Nerve growth factor (beta polypeptide)
Expression System
CHO Stable Cells
Tag
No tag
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 96 % as determined by SDS-PAGE.
Activity
Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The EDfor this effect is 1-6 ng/mL.
Form
Lyophilized
Buffer
Lyophilized from sterile 150mM NaCl, 50mM NaAc, pH 5.5. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
Function
Diagnostic proteins, Growth Factor proteins, Cytokine Proteins, Cell Therapy proteins, Biomarker Proteins, Biological Target proteins
Molecular Weight
The recombinant mouse NGF consists of 121 amino acids and has a calculated molecular mass of 13.5 kDa as estimated in SDS-PAGE under reducing conditions.
Storage Conditions
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
NGF
Species
Mouse
Protein ID
NP_001106168.1
AA Sequence
Ser122-Gly241
Protein ID Link
https://www.ncbi.nlm.nih.gov/protein/NP_001106168.1

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