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NGF Protein, Human, Recombinant

CAT: 0882-PH50981M0Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0882-PH50981M0Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Nerve growth factor (NGF) is important for the development and maintenance of the sympathetic and sensory nervous systems. NGF protein was identified as a large complex consisting of three non-covalently linked subunits, α, β, and γ, among which, the β subunit, called β-NGF (beta-NGF), was demonstrated to exhibits the growth-stimulating activity of NGF protein. NGFB/beta-NGF gene is a member of the NGF-beta family and encodes a secreted protein that homodimerizes and is incorporated into a larger complex. NGF protein acts via at least two receptors on the surface of cells (TrkA and p75 receptors) to regulate neuronal survival, promote neurite outgrowth, and up-regulate certain neuronal functions such as mediation of pain and inflammation. Also, previous studies indicated that NGF may also have an important role in the regulation of the immune system.
Overview
A DNA sequence encoding the human NGF (NP_002497.2, with mutation Arg 121 Gly) (Met1-Ala241) was expressed.
Synonyms
Beta-NGF Protein, Human; HSAN5 Protein, Human; NGFB Protein, Human
Gene Name
Nerve growth factor (beta polypeptide)
Expression System
HEK293 Cells
Tag
No tag
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
Purity
> 95 % as determined by SDS-PAGE.
Activity
Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The EDfor this effect is typically 5-20 ng/mL.
Form
Lyophilized
Buffer
Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
Function
Biomarker Proteins, Cell Therapy proteins, Diagnostic proteins, Biological Target proteins
Molecular Weight
The recombinant human NGF consists of 223 amino acids and predicts a molecular mass of 24.8 kDa.
Storage Conditions
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
NGF
Species
Human
Protein ID
NP_002497.2
AA Sequence
Met1-Ala241
Protein ID Link
https://www.ncbi.nlm.nih.gov/protein/NP_002497.2

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