CDKN2C Antibody : HRP (ARP30196_P050-HRP)

• Gene Name:

  Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)

• Gene Aliases:

  P18, INK4C, p18-INK4C

• Gene ID:

  1031

• Swiss Prot:

  P42773

• Accession Number:

  NP_001253

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit

• Immunogen:

  The immunogen is a synthetic peptide directed towards the following sequence VMKLGNPEIARRLLLRGANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQ

• Target:

  The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported.

• Partner Proteins:

  NIF3L1; NAGK; AHCYL1; UBC; TCF12; TCF4; REL; CDK6; CDK4; GOPC; LY96; MAPK10; MAPK8; PPP2CA; ATR; ATM; COPS6; CCDC90B; RBM48; UNC119; DRAP1; GDF9; NHP2L1; TLE1; CDKN2A; TP53; APLP1; LRIF1; QPCTL

• Clonality:

  Polyclonal

• Conjugation:

  HRP: Horseradish Peroxidase

• Type:

  Polyclonal Antibody

• Applications:

  IHC

• Purification:

  Affinity Purified

• Concentration:

  0.5 mg/ml

• Homology:

  Cow: 100%; Dog: 100%; Guinea Pig: 92%; Horse: 100%; Human: 100%; Mouse: 91%; Pig: 100%; Rabbit: 100%; Rat: 92%

• Format:

  Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

• Reconstitution:

  All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

• Molecular Weight:

  18 kDa

• Shipping Conditions:

  Wet Ice

• Protein Length:

  168

• NCBI Gene Symbol:

  CDKN2C

• NCBI GB Accession Number:

  CDKN2C

• Host or Source:

  Rabbit

• Protein Name:

  Cyclin-dependent kinase 4 inhibitor C

• Nucleotide Accession Number:

  NM_001262

• Peptide Sequence:

  VMKLGNPEIARRLLLRGANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQ