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UN93B rabbit pAb

CAT: 0855-ES12420-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES12420-01Size:50 µL
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Background
This gene encodes a protein that is involved in innate and adaptive immune response by regulating toll-like receptor signaling. The encoded protein traffics nucleotide sensing toll-like receptors to the endolysosome from the endoplasmic reticulum. Deficiency of the encoded protein has been associated with herpes simplex encephalitis. [provided by RefSeq, Feb 2014]
Description
This gene encodes a protein that is involved in innate and adaptive immune response by regulating toll-like receptor signaling. The encoded protein traffics nucleotide sensing toll-like receptors to the endolysosome from the endoplasmic reticulum. Deficiency of the encoded protein has been associated with herpes simplex encephalitis. [provided by RefSeq, Feb 2014],
UniProt
Q9H1C4
Swiss Prot
Q9H1C4
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from human UN93B AA range: 347-397
Target
UN93B
Clonality
Polyclonal
Source
Rabbit
Applications
WB
Concentration
1 mg/ml
Dilution
WB 1:500-2000
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Endoplasmic reticulum membrane ; Multi-pass membrane protein . Endosome . Lysosome . Cytoplasmic vesicle, phagosome . Relocalizes from endoplasmic reticulum to endosome and lysosome upon cell-stimulation with CpG dinucleotides (By similarity) . Colocalizes with LAMP5 in large endosomal intracellular vesicles. .
Gene ID (Human)
81622

UniProtKB · Q9H1C4

Protein unc-93 homolog B1

UN93B_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9H1C4
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
UNC93B1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Unc-93B1, hUNC93B1
EC number
—
Processing
—
Secondary accessions
O95764, Q569H6, Q710D4
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Biological process

Adaptive immunityAntiviral defenseImmunityInnate immunity

Cellular component

Cytoplasmic vesicleEndoplasmic reticulumEndosomeLysosomeMembrane

PTM

GlycoproteinPhosphoprotein

Domain

TransmembraneTransmembrane helix

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