(-) - (S) -Equol

• Description:

  (-) - (S) -Equol is a high affinity ligand for estrogen receptor β with a Ki of 0.73 nM.

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H335

• Target:

  Endogenous Metabolite; Estrogen Receptor/ERR

• Type:

  Natural Products

• Related Pathways:

  Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer; Metabolic Disease; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/_-_-_S_-Equol.html

• Purity:

  99.89

• Solubility:

  DMSO : 100 mg/mL (ultrasonic; warming)

• Smiles:

  OC1=CC=C2C[C@H](COC2=C1)C3=CC=C(C=C3)O

• Molecular Formula:

  C15H14O3

• Molecular Weight:

  242.27

• Precautions:

  H315, H319, H335

• References & Citations:

  [1]Setchell KD, et al. S-equol, a potent ligand for estrogen receptor beta, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora. Am J Clin Nutr. 2005 May;81 (5) :1072-9.|[2]Lu Z, et al. S-equol, a Secondary Metabolite of Natural Anticancer Isoflavone Daidzein, Inhibits Prostate Cancer Growth In Vitro and In Vivo, Though Activating the Akt/FOXO3a Pathway. Curr Cancer Drug Targets. 2016;16 (5) :455-65.|[3]Horiuchi H, et al. S-equol nantioselectively activates cAMP-protein kinase A signaling and reduces alloxan-induced cell death in INS-1 pancreatic β-cells. J Nutr Sci Vitaminol (Tokyo) . 2014;60 (4) :291-6.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  Phase 2

• Isoform:

  Human Endogenous Metabolite

• CAS Number:

  531-95-3