(±) -Equol

• Description:

  (±) -Equol is the racemate of equol. (±) -equol exhibits EC50s of 200 and 74 nM for human ERα and ERβ, respectively. Equol is a metabolite of the soy isoflavones, daidzin and daidzein.

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Drug Metabolite; Estrogen Receptor/ERR

• Type:

  Natural Products

• Related Pathways:

  Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer; Neurological Disease; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/__plusmn__-Equol.html

• Concentration:

  10mM

• Purity:

  99.79

• Solubility:

  DMSO : ≥ 100 mg/mL|H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  OC1=CC=C2CC (C3=CC=C (O) C=C3) COC2=C1

• Molecular Formula:

  C15H14O3

• Molecular Weight:

  242.27

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Axelson M, et al. The identification of the weak oestrogen equol [7-hydroxy-3- (4'-hydroxyphenyl) chroman] in human urine. Biochem J. 1982 Feb 1;201 (2) :353-7.|[2]Setchell KD, et al. S-equol, a potent ligand for estrogen receptor beta, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora. Am J Clin Nutr. 2005 May;81 (5) :1072-9. human intestinal bacterial flora.|[3]Wang J, et al. Equol promotes rat osteoblast proliferation and differentiation through activating estrogen receptor. Genet Mol Res. 2014 Jul 4;13 (3) :5055-63.|[4]Gimenez I, et al. Renal and vascular actions of equol in the rat. J Hypertens. 1997 Nov;15 (11) :1303-8.|[5]Choi EJ, et al. Anticancer mechanism of equol in 7,12-dimethylbenz (a) anthracene-treated animals. Int J Oncol. 2011 Sep;39 (3) :747-54.|[6]Charoenthongtrakul S, et al. Enhanced gastrointestinal motility with orally active ghrelin receptor agonists. J Pharmacol Exp Ther. 2009;329 (3) :1178-1186.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  94105-90-5