Thioridazine (hydrochloride) (Standard)

• UNSPSC Description:

  Thioridazine (hydrochloride) (Standard) is the analytical standard of Thioridazine (hydrochloride). This product is intended for research and analytical applications. Thioridazine hydrochloride, an orally active antagonist of the dopamine receptor D2 family proteins, exhibits potent anti-psychotic and anti-anxiety activities. Thioridazine hydrochloride is also a potent inhibitor of PI3K-Akt-mTOR signaling pathways with anti-angiogenic effect. Thioridazine hydrochloride shows antiproliferative and apoptosis induction effects in various types of cancer cells, with specificity on targeting cancer stem cells (CSCs)[1][2][3][4].

• Target Antigen:

  5-HT Receptor; Apoptosis; Autophagy; Bacterial; Dopamine Receptor

• Type:

  Reference Standards

• Related Pathways:

  Anti-infection;Apoptosis;Autophagy;GPCR/G Protein;Neuronal Signaling

• Field of Research:

  Cancer; Infection; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/thioridazine-hydrochloride-standard.html

• Solubility:

  DMSO : ≥ 45 mg/mL

• Smiles:

  CSC(C=C1N2CCC3N(C)CCCC3)=CC=C1SC4=C2C=CC=C4.[H]Cl

• Molecular Weight:

  407.04

• References & Citations:

  [1]Tschanz JT, et, al. Atypical antipsychotic drugs block selective components of amphetamine-induced stereotypy. Pharmacol Biochem Behav. 1988 Nov;31(3):519-22.|[2]Mu J, et, al. Thioridazine, an antipsychotic drug, elicits potent antitumor effects in gastric cancer. Oncol Rep. 2014 May;31(5):2107-14.|[3]Aguilar-Vega L, et, al. Antibacterial properties of phenothiazine derivatives against multidrug-resistant Acinetobacter baumannii strains. J Appl Microbiol. 2021 Apr 22.|[4]Kang S, et, al. Thioridazine induces apoptosis by targeting the PI3K/Akt/mTOR pathway in cervical and endometrial cancer cells. Apoptosis. 2012 Sep;17(9):989-97.|[5]Loehr AR, et, al. Targeting Cancer Stem Cells with Differentiation Agents as an Alternative to Genotoxic Chemotherapy for the Treatment of Malignant Testicular Germ Cell Tumors. Cancers (Basel). 2021 Apr 23;13(9):2045.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  Launched

• CAS Number:

  130-61-0