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Thioridazine (Standard)

CAT: 0804-HY-B0965AR-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0965AR-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Thioridazine (Standard) is the analytical standard of Thioridazine. This product is intended for research and analytical applications. Thioridazine, an antagonist of the dopamine receptor D2 family proteins, exhibits potent anti-psychotic and anti-anxiety activities. Thioridazine is also a potent inhibitor of PI3K-Akt-mTOR signaling pathways with anti-angiogenic effect. Thioridazine shows antiproliferative and apoptosis induction effects in various types of cancer cells, with specificity on targeting cancer stem cells (CSCs) [1][2][3][4].
CAS Number
50-52-2
UNSPSC
12352005
Target
5-HT Receptor; Apoptosis; Autophagy; Bacterial; Dopamine Receptor; Reference Standards
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Autophagy; GPCR/G Protein; Neuronal Signaling; Others
Field of Research
Neurological Disease; Cancer
Smiles
CSC(C=C1N2CCC3N(C)CCCC3)=CC=C1SC4=C2C=CC=C4
Molecular Formula
C21H26N2S2
Molecular Weight
370.57
References & Citations
[1]Tschanz JT, et, al. Atypical antipsychotic drugs block selective components of amphetamine-induced stereotypy. Pharmacol Biochem Behav. 1988 Nov;31 (3) :519-22.|[2]Mu J, et, al. Thioridazine, an antipsychotic drug, elicits potent antitumor effects in gastric cancer. Oncol Rep. 2014 May;31 (5) :2107-14.|[3]Kang S, et, al. Thioridazine induces apoptosis by targeting the PI3K/Akt/mTOR pathway in cervical and endometrial cancer cells. Apoptosis. 2012 Sep;17 (9) :989-97.|[4]Loehr AR, et, al. Targeting Cancer Stem Cells with Differentiation Agents as an Alternative to Genotoxic Chemotherapy for the Treatment of Malignant Testicular Germ Cell Tumors. Cancers (Basel) . 2021 Apr 23;13 (9) :2045.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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