Chlormethine (hydrochloride) (Standard)

• UNSPSC Description:

  Chlormethine (hydrochloride) (Standard) is the analytical standard of Chlormethine (hydrochloride). This product is intended for research and analytical applications. Chlormethine hydrochloride is a foaming agent that causes necrotic and irritating damage to mucous membranes. Used as an antitumor agent in Hodgkin's disease and lymphoma.

• Target Antigen:

  Others

• Type:

  Reference compound

• Related Pathways:

  Others

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/chlormethine-hydrochloride-standard.html

• Smiles:

  ClCCN(CCCl)C.[H]Cl

• Molecular Weight:

  192.51

• References & Citations:

  [1]Cao Z, et al. Effect of brentuximab vedotin combined with chlormethine hydrochloride on the treatment of 6 patients with relapsed and refractory Hodgkin lymphoma. Zhonghua Xue Ye Xue Za Zhi. 2015 Jul 14;36(7):575-577.|[2]Yuan Yang, et al. Chlormethine Hydrochloride is Not Inferior to Tacrolimus in Treating Steroid-Resistant Nephrotic Syndrome. Kidney Blood Press Res. 2018;43(1):68-79.|[3]Liren Tang, et al. Topical mechlorethamine restores autoimmune-arrested follicular activity in mice with an alopecia areata-like disease by targeting infiltrated lymphocytes. J Invest Dermatol. 2003 Mar;120(3):400-6.|[4]K Bryniarski, et al. The in vivo and in vitro effects of an alkylating agent, mechlorethamine, on IL-6 production in mice and the role of macrophages. Immunopharmacology. 1996 Sep;34(2-3):73-8.

• Shipping Conditions:

  Room temperature

• CAS Number:

  55-86-7