Chlormethine (hydrochloride) (Standard)

Chlormethine (hydrochloride) (Standard)

• CAS Number: 55-86-7
• UNSPSC Description: Chlormethine (hydrochloride) (Standard) is the analytical standard of Chlormethine (hydrochloride). This product is intended for research and analytical applications. Chlormethine hydrochloride is a foaming agent that causes necrotic and irritating damage to mucous membranes. Used as an antitumor agent in Hodgkin's disease and lymphoma.
• Target Antigen: Others
• Type: Reference compound
• Related Pathways: Others
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/chlormethine-hydrochloride-standard.html
• Smiles: ClCCN(CCCl)C.[H]Cl
• Molecular Weight: 192.51
• References & Citations: [1]Cao Z, et al. Effect of brentuximab vedotin combined with chlormethine hydrochloride on the treatment of 6 patients with relapsed and refractory Hodgkin lymphoma. Zhonghua Xue Ye Xue Za Zhi. 2015 Jul 14;36(7):575-577.|[2]Yuan Yang, et al. Chlormethine Hydrochloride is Not Inferior to Tacrolimus in Treating Steroid-Resistant Nephrotic Syndrome. Kidney Blood Press Res. 2018;43(1):68-79.|[3]Liren Tang, et al. Topical mechlorethamine restores autoimmune-arrested follicular activity in mice with an alopecia areata-like disease by targeting infiltrated lymphocytes. J Invest Dermatol. 2003 Mar;120(3):400-6.|[4]K Bryniarski, et al. The in vivo and in vitro effects of an alkylating agent, mechlorethamine, on IL-6 production in mice and the role of macrophages. Immunopharmacology. 1996 Sep;34(2-3):73-8.
• Shipping Conditions: Room temperature