Products for Research Use Only
RegisterLogin

Top1/2-IN-1

CAT: 0804-HY-161957Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-161957Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Top1/2-IN-1 (compound 23) is an orally available dual inhibitor of Top1/2 with antiproliferative activity. Top1/2-IN-1 damages DNA with increased levels of reactive oxygen species, inducing apoptosis and cell cycle arrest in cancer cells. Top1/2-IN-1 exhibits in vivo antitumor activity in xenograft models[1].
UNSPSC
12352005
Target
Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/top1-2-in-1.html
Smiles
CN(C)CCCN1C2=C(C=C(OCO3)C3=C2)C4=C1C5=CC=CC=C5C=N4
Molecular Formula
C21H21N3O2
Molecular Weight
347.41
References & Citations
[1]Discovery of Indolo[3,2-c]isoquinoline Derivatives as Novel Top1/2 Dual Inhibitors with Orally Efficacious Antitumor Activity and Low Toxicity
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-159935Top1-IN-2
HY-126142-01Top1 inhibitor 1
HY-P73585-01TOP1, Human (575a.a, sf9, His)
HY-P73584-01TOP1, Human (765a.a, sf9, His)
HY-RS14892Top1 Rat Pre-designed siRNA Set A
HY-RS14890TOP1 Human Pre-designed siRNA Set A
HY-RS14891Top1 Mouse Pre-designed siRNA Set A
HY-150685Topo I/COX-2-IN-1
HY-W131797-011-Iodoethane-1,1,2,2,2-d5
HY-W752879Succinyl (choline-1,1,1',1',2,2,2',2') Bromide-d8

Alternative Products

CatalogName
GTR19239049-01Top1/2-IN-1
T206637-01Top1-IN-2
GTR19204607-01Top1 inhibitor 1
529210-01TOP1
T5008-76BThimet Oligopeptidase 1 (TOP1)
A13304-1Top1 inhibitor 1 1mg
A13304-100Top1 inhibitor 1 100mg
A13304-25Top1 inhibitor 1 25mg
A13304-5Top1 inhibitor 1 5mg
A13304-50Top1 inhibitor 1 50mg

Popular Products