PCSK9 rabbit pAb

CAT: 0855-ES20358-01Size: 50 µLDry Ice: NoHazardous: No

1 / 1

CAT#:0855-ES20358-01Size:50 µL

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Background

Cofactor:Calcium., disease:Defects in PCSK9 are the cause of familial hypercholesterolemia 3 (FH3) [MIM:603776]. FH3 inheritance is autosomal dominant., enzyme regulation:Inhibited by EGTA., function:May be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis., PTM:The soluble zymogen undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted enzyme., similarity:Belongs to the peptidase S8 family., similarity:Contains 1 peptidase S8 domain., subunit:The precursor protein but not the mature protein may form multimers., tissue specificity:Expressed in neuro-epithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells.

Description

Cofactor: Calcium. Disease: Defects in PCSK9 are the cause of familial hypercholesterolemia 3 (FH3) [MIM: 603776]. FH3 inheritance is autosomal dominant. enzyme regulation: Inhibited by EGTA. function: May be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis. PTM: The soluble zymogen undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted enzyme. similarity: Belongs to the peptidase S8 family. similarity: Contains 1 peptidase S8 domain. subunit: The precursor protein but not the mature protein may form multimers. tissue specificity: Expressed in neuro-epithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells.

UniProt

Q8NBP7

Swiss Prot

Q8NBP7

Reactivity

Human; Rat; Mouse

Immunogen

Synthesized peptide derived from human PCSK9

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IHC

Concentration

1 mg/ml

Dilution

WB 1:500-2000; IHC-p 1:50-300

Storage Conditions

-20°C/1 year

Fragment

IgG

Subcellular Location

Cytoplasm. Secreted. Endosome. Lysosome. Cell surface. Endoplasmic reticulum. Golgi apparatus. Autocatalytic cleavage is required to transport it from the endoplasmic reticulum to the Golgi apparatus and for the secretion of the mature protein. Localizes to the endoplasmic reticulum in the absence of LDLR and colocalizes to the cell surface and to the endosomes/lysosomes in the presence of LDLR. The sorting to the cell surface and endosomes is required in order to fully promote LDLR degradation.

Other Product Names

Proprotein convertase subtilisin/kexin type 9 (EC 3.4.21.-; Neural apoptosis-regulated convertase 1; NARC-1; Proprotein convertase 9; PC9; Subtilisin/kexin-like protease PC9)

Gene ID (Human)

255738

UniProtKB · Q8NBP7

Proprotein convertase subtilisin/kexin type 9

PCSK9_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q8NBP7
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: PCSK9
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: 3.4.21.-
Processing: Precursor
Secondary accessions: A8T640, C0JYY9, Q5PSM5, Q5SZQ2

Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisCholesterol metabolismLipid metabolismSteroid metabolismSterol metabolism

PTM

Autocatalytic cleavageDisulfide bondGlycoproteinPhosphoproteinSulfationZymogen

Ligand

Calcium

Cellular component

CytoplasmEndoplasmic reticulumEndosomeGolgi apparatusLysosomeSecreted

Disease

Disease variant

Molecular function

HydrolaseProteaseSerine protease

Domain

Signal

Related Products

Catalog	Name
ES14195-01	PCSK6 rabbit pAb
ES14196-01	PCSK5 rabbit pAb
ES4666-01	RAB3IP rabbit pAb
ES20751-01	Gab1 Rabbit rabbit pAb
ES20703-01	JAK2 Rabbit rabbit pAb
ES20758-01	ERK1 Rabbit rabbit pAb
ES20830-01	ATG14L Rabbit rabbit pAb
ES20829-01	ATG4a Rabbit rabbit pAb
ES20658-01	NM23A Rabbit rabbit pAb
ES20826-01	ATG5 Rabbit rabbit pAb

Alternative Products

Catalog	Name
MBS8603216-01	PCSK9 Rabbit mAb
MBS8543325-01	PCSK9 Rabbit pAb
GTR18216001-01	Rabbit PCSK9 Antibody