8-Br-7-CH-cADPR

CAT:

804-HY-134269

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CAS Number: 189876-06-0
UNSPSC Description: 8-Br-7-CH-cADPR (7-Deaza-8-bromo-cADPR) is a potent cADPR antagonist. 8-Br-7-CH-cADPR shows partial inhibition of calcium elevation caused by sTIR dimerization. 8-Br-7-CH-cADPR significantly decreases Paclitaxel (HY-B0015)-induced axon degeneration[1].
Target Antigen: Calcium Channel
Type: Reference compound
Related Pathways: Membrane Transporter/Ion Channel;Neuronal Signaling
Field of Research: Neurological Disease
Assay Protocol: https://www.medchemexpress.com/8-br-7-ch-cadpr.html
Smiles: N=C1C(C=C(Br)N2[C@H]3[C@H](O)[C@H](O)[C@@H](COP4(O)=O)O3)=C2N=CN1[C@H]5[C@H](O)[C@H](O)[C@@H](COP(O)(O4)=O)O5
Molecular Weight: 619.21
References & Citations: [1]Yihang Li, et al. Sarm1 activation produces cADPR to increase intra-axonal Ca++ and promote axon degeneration in PIPN. J Cell Biol. 2022 Feb 7;221(2):e202106080.
Shipping Conditions: Room temperature
Clinical Information: No Development Reported

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sc-201514A	8-Bromo-cADP-Ribose (8-Br-cADPR)
sc-201514	8-Bromo-cADP-Ribose (8-Br-cADPR)
MBS256189-01	beta- Nicotinamide- 8- bromo- 7- deazaadenine dinucleotide (8-Br-7-CH-NAD+)
MBS256189-02	beta- Nicotinamide- 8- bromo- 7- deazaadenine dinucleotide (8-Br-7-CH-NAD+)
MBS256501-02	8- Bromo- cyclic adenosine diphosphate ribose (8-Br-cADPR)
MBS256044-01	8- Bromo- 7- deazaadenosine- 5'- O- diphosphoribose (8-Br-7-CH-ADPR)
MBS256044-02	8- Bromo- 7- deazaadenosine- 5'- O- diphosphoribose (8-Br-7-CH-ADPR)
MBS256501-01	8- Bromo- cyclic adenosine diphosphate ribose (8-Br-cADPR)