8-Br-7-CH-cADPR

• UNSPSC Description:

  8-Br-7-CH-cADPR (7-Deaza-8-bromo-cADPR) is a potent cADPR antagonist. 8-Br-7-CH-cADPR shows partial inhibition of calcium elevation caused by sTIR dimerization. 8-Br-7-CH-cADPR significantly decreases Paclitaxel (HY-B0015)-induced axon degeneration[1].

• Target Antigen:

  Calcium Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel;Neuronal Signaling

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/8-br-7-ch-cadpr.html

• Smiles:

  N=C1C(C=C(Br)N2[C@H]3[C@H](O)[C@H](O)[C@@H](COP4(O)=O)O3)=C2N=CN1[C@H]5[C@H](O)[C@H](O)[C@@H](COP(O)(O4)=O)O5

• Molecular Weight:

  619.21

• References & Citations:

  [1]Yihang Li, et al. Sarm1 activation produces cADPR to increase intra-axonal Ca++ and promote axon degeneration in PIPN. J Cell Biol. 2022 Feb 7;221(2):e202106080.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  189876-06-0