8-Br-GTP

• Description:

  8-Br-GTP, a GTP analog, is a competitive FtsZ polymerization and GTPase activity (Ki of 31.8 μM) inhibitor. 8-Br-GTP can be used for nucleic acid modification[1].

• Product Name Alternative:

  8-Bromoguanosine-5'-triphosphate

• UNSPSC:

  12352005

• Target:

  Bacterial

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/8-br-gtp.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=P (O) (O) OP (OP (OC[C@@H]1[C@@H] (O) [C@@H] (O) [C@H] (N2C (Br) =NC3=C2NC (N) =NC3=O) O1) (O) =O) (O) =O

• Molecular Formula:

  C10H15BrN5O14P3

• Molecular Weight:

  602.08

• References & Citations:

  [1]Tilman Läppchen, et al. GTP analogue inhibits polymerization and GTPase activity of the bacterial protein FtsZ without affecting its eukaryotic homologue tubulin. Biochemistry. 2005 May 31;44 (21) :7879-84.|[2]Jozef Hritz, et al. Optimization of replica exchange molecular dynamics by fast mimicking. J Chem Phys. 2007 Nov 28;127 (20) :204104.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  23197-98-0