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8-Br-GTP

CAT: 0804-HY-134274Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-134274Size:1 Each
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Description
8-Br-GTP, a GTP analog, is a competitive FtsZ polymerization and GTPase activity (Ki of 31.8 μM) inhibitor. 8-Br-GTP can be used for nucleic acid modification[1].
CAS Number
[23197-98-0]
Product Name Alternative
8-Bromoguanosine-5'-triphosphate
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/8-br-gtp.html
Solubility
10 mM in DMSO
Smiles
O=P(O)(O)OP(OP(OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(Br)=NC3=C2NC(N)=NC3=O)O1)(O)=O)(O)=O
Molecular Formula
C10H15BrN5O14P3
Molecular Weight
602.08
References & Citations
[1]Tilman Läppchen, et al. GTP analogue inhibits polymerization and GTPase activity of the bacterial protein FtsZ without affecting its eukaryotic homologue tubulin. Biochemistry. 2005 May 31;44 (21) :7879-84.|[2]Jozef Hritz, et al. Optimization of replica exchange molecular dynamics by fast mimicking. J Chem Phys. 2007 Nov 28;127 (20) :204104.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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