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FIIN-3

CAT: 0804-HY-18603-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-18603-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FIIN-3 is an irreversible inhibitor of FGFR with an IC50 of 13.1, 21, 31.4, and 35.3 nM for FGFR1, FGFR2, FGFR3 and FGFR4, respectively.
CAS Number
1637735-84-2
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
EGFR; FGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/FIIN-3.html
Purity
99.66
Solubility
DMSO : 10 mg/mL (ultrasonic; warming)
Smiles
C=CC(NC1=CC=C(CN(C(NC2=C(Cl)C(OC)=CC(OC)=C2Cl)=O)C3=NC=NC(NC4=CC=C(N5CCN(C)CC5)C=C4)=C3)C=C1)=O
Molecular Formula
C34H36Cl2N8O4
Molecular Weight
691.61
Precautions
H302, H315, H319, H335
References & Citations
[1]Tan L et al. Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors. Proc Natl Acad Sci U S A, 2014 Nov 11, 111 (45) :E4869-77
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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Alternative Products

CatalogName
BA6366-50FIIN-3
450062FIIN-​3
A15848-200FIIN-3 200mg
A15848-10FIIN-3 10mg
A15848-1FIIN-3 1mg
A15848-50FIIN-3 50mg
A15848-5FIIN-3 5mg
A15848-100FIIN-3 100mg
A15848-25FIIN-3 25mg
A15848-2FIIN-3 2mg

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