FIIN-4

• Description :

  FIIN-4 is a first-in-class, orally active and covalent FGFR inhibitor with IC50s of 2.6 nM, 2.6 nM, 5.6 nM, 9.2 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively. FIIN-4 can inhibit metastatic tumor growth.

• UNSPSC :

  12352005

• Target :

  FGFR

• Type :

  Reference compound

• Related Pathways :

  Protein Tyrosine Kinase/RTK

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/fiin-4.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C1N(C2=NC(NC3=CC=C(C=C3)N4CCN(CC4)C)=NC=C2CN1C5=CC(OC)=CC(OC)=C5)CC6=CC=CC(NC(C=C)=O)=C6

• Molecular Formula :

  C35H38N8O4

• Molecular Weight :

  634.73

• References & Citations :

  [1]Wells S Brown, et al. Covalent Targeting of Fibroblast Growth Factor Receptor Inhibits Metastatic Breast Cancer. Mol Cancer Ther. 2016 Sep;15 (9) :2096-106.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2093088-81-2]