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FIIN-4

CAT: 0804-HY-123134Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-123134Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FIIN-4 is a first-in-class, orally active and covalent FGFR inhibitor with IC50s of 2.6 nM, 2.6 nM, 5.6 nM, 9.2 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively. FIIN-4 can inhibit metastatic tumor growth.
CAS Number
[2093088-81-2]
UNSPSC
12352005
Target
FGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fiin-4.html
Solubility
10 mM in DMSO
Smiles
O=C1N(C2=NC(NC3=CC=C(C=C3)N4CCN(CC4)C)=NC=C2CN1C5=CC(OC)=CC(OC)=C5)CC6=CC=CC(NC(C=C)=O)=C6
Molecular Formula
C35H38N8O4
Molecular Weight
634.73
References & Citations
[1]Wells S Brown, et al. Covalent Targeting of Fibroblast Growth Factor Receptor Inhibits Metastatic Breast Cancer. Mol Cancer Ther. 2016 Sep;15 (9) :2096-106.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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