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Recombinant Human IGF-I (67AA)

CAT: 0855-EPT091Size: 50 µgDry Ice: NoHazardous: No
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CAT#:0855-EPT091Size:50 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Insulin-like growth factor I (IGF1) belongs to the family of insulin-like growth factors that are structurally homologous to proinsulin. Mature IGFs are generated by proteolytic processing of inactive precursor protein containing N-terminal and C-terminal propeptide regions. Mature human IGF-I consisting of 70 amino acids with 94% identity with mouse IGF1 and exhibits cross-species activity. IGF1 binds IGF-1R, IGF-2R, and the insulin receptor and plays a key role in cell cycle progression, cell proliferation and tumor progression. IGF1 expression is regulated by growth hormone.
Description
Recombinant Human Insulin-like Growth Factor I (4-70) is produced by our E.coli expression system and the target gene encoding Thr52-Ala118 is expressed.
UniProt
P05019
Accession Number
P05019
Endotoxin
Less than 0.05 ng/μg (0.5 EU/μg) as determined by LAL test.
Purity
Greater than 95% as determined by reducing SDS-PAGE.
Molecular Weight
7.3 KDa
Shipping Conditions
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
Storage Conditions
Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Storage Temperature
Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Notes
Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Observed Molecular Weight
9 KDa, reducing conditions
Other Product Names
Insulin-Like Growth Factor I; IGF-I; Mechano Growth Factor; MGF; Somatomedin-C; IGF1; IBP1

UniProtKB · P05019

Insulin-like growth factor 1

IGF1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P05019
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
IGF1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
B2RWM7, E9PD02, P01343, Q14620
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Disease

DeafnessDwarfismIntellectual disability

PTM

Disulfide bond

Molecular function

Growth factor

Cellular component

Secreted

Domain

Signal

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