IGF-IR rabbit pAb

CAT: 0855-ES2595-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0855-ES2595-01Size:50 µL
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Background
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
Description
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014],
UniProt
P08069/P06213
Swiss Prot
P08069/P06213
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human IGF1R. AA range:1126-1175
Clonality
Polyclonal
Source
Rabbit
Applications
IF; WB; IHC; ELISA
Concentration
1 mg/ml
Dilution
IF: 1:50-200 Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Molecular Weight
pro: 155kD, recetor beta: 95kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
Pro: 155kD, recetor beta: 95kD
Fragment
IgG
Subcellular Location
Cell membrane ; Single-pass type I membrane protein .
Other Product Names
IGF1R; Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD antigen CD221; INSR; Insulin receptor; IR; CD antigen CD220
Gene ID (Human)
3480/3643

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