DYRKs-IN-1 (hydrochloride)

DYRKs-IN-1 (hydrochloride)

• CAS Number: 1386980-55-7
• UNSPSC Description: DYRKs-IN-1 hydrochloride is a potent DYRKs (Dual-specificity tyrosine-phosphorylation-regulated kinases) inhibitor with IC50s of 5 nM and 8 nM for DYRK1A and DYRK1B, respectively. DYRKs-IN-1 hydrochloride has antitumor activity[1][2].
• Target Antigen: DYRK
• Type: Reference compound
• Related Pathways: Protein Tyrosine Kinase/RTK
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/dyrks-in-1-hydrochloride.html
• Purity: 99.71
• Solubility: DMSO : 20.83 mg/mL (ultrasonic;warming;heat to 60°C)|H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: O=C(C1=CC2=CN=C(N3CC(O4)CCC4C3)N=C2NC1=O)NC5=CC(C(NC(C6=CC=CC=C6)CCN)=O)=CC=C5Cl.[H]Cl
• Molecular Weight: 624.52
• References & Citations: [1]Anderson K, et al. Pyrido[2,3-d]pyrimidines: discovery and preliminary SAR of a novel series of DYRK1B and DYRK1A inhibitors. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6610-5.|[2]Kevin Anderson, et al. Pyrido pyrimidines. US20120184542A1.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported