Anti-DAP Kinase 2 Antibody

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CAT:

14-2323-1

Size:

100 µg

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Anti-DAP Kinase 2 Antibody

Description: Rabbit Polyclonal Antibody specific to DAPK2
Alternative Name: DAP kinase 2, EC 2.7.11.1, DAP-kinase-related protein 1, DRP-1
Gene Name: DAPK2
Gene ID: 23604
NCBI Gene ID: DAPK2
UniProt: Q9UIK4
Accession Number: NP_055141.2
Cellular Locus: Cytoplasm. Cytoplasmic vesicle, autophagosome lumen.
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Peptide corresponding to aa 356-370 of human DAPK2 (accession no. BAA88063). This sequence is identical to that of mouse.
Target Antigen: Death-associated protein kinase 2
Target: DAP Kinase 2
Clonality: Polyclonal
Isotype: IgG
Type: Antibody
Applications: ELISA, WB, IHC-P
Field of Research: Apoptosis
Purification Method: Purified by peptide immuno-affinity chromatography
Concentration: Lot Specific
Dilution: Dilute in PBS or medium which is identical to that used in the assay system.
Format: Purified
Form: Liquid
Buffer: Phosphate Buffered Saline
Function: Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell death signals, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation (PubMed:17347302). Regulates granulocytic motility by controlling cell spreading and polarization (PubMed:24163421). {PubMed:17347302, PubMed:24163421, PubMed:26047703}.; Isoform 2 is not regulated by calmodulin. It can phosphorylate MYL9. It can induce membrane blebbing and autophagic cell death.
Additionnal Information: Immunoblotting: use at 1ug/mL.

Immunohistochemistry: use at 2ug/mL.

These are recommended concentrations.

Enduser should determine optimal concentrations for their applications.

Positive control: Whole cell lysate from A431cells.
Storage Conditions: This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles.
Specificity: This antibody recognizes human, mouse, and rat DAPK2 (approx. 42kDa) and does not cross- react with DAPK.
Formulation: PBS, pH 7.4.
Buffer pH: pH 7.4
Target Background: Certain serine/threonine protein kinases, such as RIP and DAP kinase, are mediators of apoptosis. DAP kinase (DAPK) is a pro- apoptotic, calcium-regulated serine/threonine kinase containing a death domain. Expression of DAPK induces cell death and suppresses oncogenic trans-formation. DAPK mediates IFN -induced apoptosis. A DAPK-related protein was recently described and designated DAPK2, or DRP-1. Expression of DAPK2 induces apoptosis. The messenger RNA for DAPK2 is expressed in multiple human tissues.

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