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Fibulin-3

CAT: 0579-X2766BSize: 50 µgDry Ice: NoHazardous: No
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CAT#:0579-X2766BSize:50 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This peptide is the immunogen used to make Cat # X2751P. _x000B__x000B_Fibulin-1 is a modular glycoprotein component of elastic extracellular matrix fibers, basement membranes and blood. It can bind calcium, Fibronectin, Laminin, Nidogen and Fibrinogen. Estrogen exposure to ovarian cancer cell lines can upregulate Fibulin-1. Fibulin-2 is abundant in heart, placenta and ovarian tissue and binds several components of the extracelllar matrix including aggrecan, versican and brevican. Fibulin-3, also known as EFEMP1, is a secreted protein. Defects in the gene for Fibulin-3 cause the autosomal dominant disease Doyne honeycomb retinal dystrophy (DHRD, also known as malattia leventinese) which is characterized by yellow-white deposits (drusen) that accumulate under the retinal pigment epithelium. Fibulin-3 is not present at the site of drusen formation in normal eyes. Fibulin-5 is an integrin-binding extracellular matrix protein that mediates endothelial cell adhesion. Blocking Peptide to Cat # X2751P.
Synonyms
EGF-containing fibulin-like extraCellular matrix Protein 1, ExtraCellular Protein S1-5, Fibulin-like Protein, EFEMP1
Type
Blocking Peptide
Applications
Blocking Peptide
Assay Principle
Optimal concentration should be evaluated by serial dilutions.
Stability
See expiration date on vial
Concentration
See vial for Concentration
Form
Provided as solution in phosphate buffered saline with 0,08% sodium azide
Precautions
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.
Shipping Conditions
Ambient Temperature, freeze upon arrival
Storage Conditions
Product should be stored at -20ºC; Aliquot to avoid freeze/thaw cycles
Functional Analysis
Neutralizing

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