UNC2541

CAT: 0804-HY-125510-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-125510-01Size:5 mg
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Description
UNC2541 is a potent and Mer tyrosine kinase (MerTK) -specific inhibitor, binds in the MerTK ATP pocket, with an IC50 of 4.4 nM, more selective over Axl, Tyro3 and Flt3. UNC2541 inhibits phosphorylated MerTK (pMerTK; EC50, 510 nM) . UNC2541 abolishes the analgesic and anti-inflammatory effects of ozone in vivo and in vitro[1][2][3].
CAS Number
[1612782-86-1]
UNSPSC
12352005
Target
TAM Receptor
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/unc2541.html
Purity
99.71
Solubility
DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C(C(NCCCC[C@@H]1N)=N2)=CN=C2NCCCCCCNC1=O)NCC3=CC=C(F)C=C3
Molecular Formula
C24H34FN7O2
Molecular Weight
471.57
References & Citations
[1]McIver AL, et al. Discovery of Macrocyclic Pyrimidines as MerTK-Specific Inhibitors. ChemMedChem. 2017 Feb 3;12 (3) :207-213.|[2]Ruan S, et al. Ozone promotes macrophage efferocytosis and alleviates neuropathic pain by activating the AMPK/Gas6-MerTK/SOCS3 signaling pathway. Front Immunol. 2024 Nov 19;15:1455771. |[3]Fan W, et al. Ozone alleviates MSU-induced acute gout pain via upregulating AMPK/GAS6/MerTK/SOCS3 signaling pathway. J Transl Med. 2023 Dec 8;21 (1) :890.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Mer

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407944UNC2541
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