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UNC2881

CAT: 0804-HY-15798-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-15798-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
UNC2881 is an orally active and specific Mer kinase inhibitor, inhibits steady-state Mer kinase phosphorylation with an IC50 value of 22 nM. UNC2881 shows additional inhibition against Axl and Tyro with IC50s of 360 nM and 250 nM, respectively. UNC2881 potently inhibits collagen-induced platelet aggregation, can be used for pathologic thrombosis research[1].
CAS Number
[1493764-08-1]
UNSPSC
12352005
Hazard Statement
H302
Target
TAM Receptor; VSV
Type
Reference compound
Related Pathways
Anti-infection; Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/UNC2881.html
Purity
99.79
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CCCCNC1=NC(N[C@H]2CC[C@H](O)CC2)=C(C(NCC3=CC=C(N4C=NC=C4)C=C3)=O)C=N1
Molecular Formula
C25H33N7O2
Molecular Weight
463.58
Precautions
H302
References & Citations
[1]Zhang W, et al. Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis. J Med Chem. 2013 Dec 12;56 (23) :9693-700.|[2]Tom Adomati, et al. Dead Cells Induce Innate Anergy Via Mertk after Acute Viral Infection. Cell Reports. 2020. 30 (11) :3671-3681.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Axl; Mer

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