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UNC2541

CAT: 0013-GTR19177881-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19177881-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
UNC2541 is a highly potent and selective small molecule inhibitor of Mer tyrosine kinase (MerTK), binding its ATP pocket with an IC50 of 4.4 nM and inhibiting phosphorylated MerTK (pMerTK) with an EC50 of 510 nM. This tool compound is widely used in vitro and in vivo to investigate MerTK's role in immunology, oncology, and efferocytosis.
CAS Number
1612782-86-1
Product Name Alternative
Mer, Flt3, Inhibitor, inhibit, pMerTK, Axl, TAMReceptor, TAM Receptor, UNC2541, UNC-2541, UNC 2541, Tyro3
Field of Research
Cardiovascular Research, Signal Transduction
Purity
98.33% (May vary between batches)
Solubility
DMSO:10 mg/mL (21.21 mM)
Smiles
N[C@H]1CCCCNc2nc (NCCCCCCNC1=O) ncc2C (=O) NCc1ccc (F) cc1
Molecular Formula
C24H34FN7O2
Molecular Weight
471.57
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

(7s)-7-Amino-N-[(4-Fluorophenyl)methyl]-8-Oxo-2,9,16,18,21-Pentaazabicyclo[15.3.1]henicosa-1(21),17,19-Triene-20-Carboxamide
CAS Number1612782-86-1
PubChem CID74538669
IUPAC Name(7S)-7-amino-N-[(4-fluorophenyl)methyl]-8-oxo-2,9,16,18,21-pentazabicyclo[15.3.1]henicosa-1(21),17,19-triene-20-carboxamide
Molecular FormulaC24H34FN7O2
Molecular Weight471.6
XLogP2.4
Topological Polar Surface Area134
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count8
Rotatable Bond Count3
Heavy Atom Count34
Formal Charge0
Complexity618
SMILES
C1CCCNC2=NC=C(C(=N2)NCCCC[C@@H](C(=O)NCC1)N)C(=O)NCC3=CC=C(C=C3)F
InChI
InChI=1S/C24H34FN7O2/c25-18-10-8-17(9-11-18)15-30-22(33)19-16-31-24-29-14-5-2-1-4-13-28-23(34)20(26)7-3-6-12-27-21(19)32-24/h8-11,16,20H,1-7,12-15,26H2,(H,28,34)(H,30,33)(H2,27,29,31,32)/t20-/m0/s1
InChIKey
ONIHBIZGUJZDHG-FQEVSTJZSA-N
Chemical Structure
2D Structure
2D structure of (7s)-7-Amino-N-[(4-Fluorophenyl)methyl]-8-Oxo-2,9,16,18,21-Pentaazabicyclo[15.3.1]henicosa-1(21),17,19-Triene-20-Carboxamide
CAS: 1612782-86-1
CID: 74538669
Formula: C24H34FN7O2
MW: 471.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight471.6
XLogP32.4
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count8
Rotatable Bond Count3
Exact Mass471.27580151
Monoisotopic Mass471.27580151
Topological Polar Surface Area134 Ų
Heavy Atom Count34
Formal Charge0
Complexity618
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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BA9030-5.1UNC2541
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A18523-5UNC2541 5mg
A18523-50UNC2541 50mg
A18523-2UNC2541 2mg
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