Amino-PEG10-amine

CAT: 0804-HY-W040270-01Size: 50 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-W040270-01Size:50 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Amino-PEG10-amine, a PEG-based PROTAC linker used to combine two mono diethylstilbestrol (DES) -based ligands, provides an alternative strategy for preparing more selective and active ER antagonists for endocrine therapy of breast cancer[1].

CAS Number

928292-69-7

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/amino-peg10-amine.html

Purity

97.0

Solubility

10 mM in DMSO

Smiles

NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN

Molecular Formula

C22H48N2O10

Molecular Weight

500.62

Precautions

H302, H315, H319, H335

References & Citations

[1]Shan M, et al. Nonsteroidal bivalent estrogen ligands: an application of the bivalent concept to the estrogen receptor. ACS Chem Biol. 2013 Apr 19;8 (4) :707-15.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PEG Linkers

Chemical Information

Amino-PEG10-Amine

CAS Number	928292-69-7
PubChem CID	77078168
IUPAC Name	2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanamine
Molecular Formula	C22H48N2O10
Molecular Weight	500.6
XLogP	-3.1
Topological Polar Surface Area	144
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	12
Rotatable Bond Count	31
Heavy Atom Count	34
Formal Charge	0
Complexity	328

SMILES

C(COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN)N

InChI

InChI=1S/C22H48N2O10/c23-1-3-25-5-7-27-9-11-29-13-15-31-17-19-33-21-22-34-20-18-32-16-14-30-12-10-28-8-6-26-4-2-24/h1-24H2

InChIKey

YMQALIUBVKNYIJ-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 928292-69-7

CID: 77078168

Formula: C22H48N2O10

MW: 500.6

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	500.6
XLogP3	-3.1
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	12
Rotatable Bond Count	31
Exact Mass	500.33089573
Monoisotopic Mass	500.33089573
Topological Polar Surface Area	144 Å²
Heavy Atom Count	34
Formal Charge	0
Complexity	328
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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HY-133328-01	Amino-PEG13-amine
HY-140217-01	Azido-PEG10-amine
HY-143827-01	Biotin-PEG10-amine
HY-133230-01	Propargyl-PEG10-amine
HY-140226-01	M-PEG10-amine
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Catalog	Name
FP72978-01	Amino-PEG10-Amine
571848	Azido-PEG10-amine
MBS5769814	Propargyl-PEG10-amine
T208191-01	Biotin-PEG10-amine
571864	m-PEG10-amine
T17402-01	Amino-PEG10-acid
T14224-01	Amino-PEG10-Boc
T14225-01	Amino-PEG10-OH

Amino-PEG10-amine

Chemical Information

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