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Carebastine-d5

CAT: 0804-HY-121356S-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-121356S-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Carebastine-d5 is the deuterium labeled Carebastine. Carebastine is the active metabolite of Ebastine. Carebastine is a histamine H1 receptor antagonist. Carebastine inhibits VEGF-induced HUVEC and HPAEC proliferation, migration and angiogenesis in a dose-dependent manner[1]. Carebastine suppresses the expression of macrophage migration inhibitory factor[2].
CAS Number
1189661-02-6
UNSPSC
12352005
Target
Histamine Receptor; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling; Others
Field of Research
Cancer; Endocrinology
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=C(C=C1)C(C)(C)C(O)=O)CCCN(CC2)CCC2OC(C3=CC=CC=C3)C4=C([2H])C([2H])=C([2H])C([2H])=C4[2H]
Molecular Formula
C32H32D5NO4
Molecular Weight
504.67
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]De Luisi A, et al. Anti-angiogenic activity of carebastine: a plausible mechanism affecting airway remodelling. Eur Respir J. 2009 Oct;34 (4) :958-66.|[3]Zhao Y, et al. Carebastine, an H1-receptor antagonist, suppresses the expression of macrophage migration inhibitory factor. Clin Exp Dermatol. 2008 Nov;33 (6) :785-7.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
H1 Receptor

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