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Carebastine

CAT: 0804-HY-121356-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-121356-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Carebastine is the active metabolite of Ebastine. Carebastine is a histamine H1 receptor antagonist. Carebastine inhibits VEGF-induced HUVEC and HPAEC proliferation, migration and angiogenesis in a dose-dependent manner[1]. Carebastine suppresses the expression of macrophage migration inhibitory factor[2].
CAS Number
90729-42-3
UNSPSC
12352005
Hazard Statement
H301, H413
Target
Histamine Receptor; Macrophage migration inhibitory factor (MIF)
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer; Endocrinology
Assay Protocol
https://www.medchemexpress.com/carebastine.html
Purity
99.23
Solubility
DMF : 25 mg/mL (ultrasonic; warming) |DMSO : 2 mg/mL (ultrasonic; warming)
Smiles
O=C(CCCN1CCC(OC(C2=CC=CC=C2)C3=CC=CC=C3)CC1)C4=CC=C(C=C4)C(C)(C(O)=O)C
Molecular Formula
C32H37NO4
Molecular Weight
499.64
Precautions
H301, H413
References & Citations
[1]De Luisi A, et al. Anti-angiogenic activity of carebastine: a plausible mechanism affecting airway remodelling. Eur Respir J. 2009 Oct;34 (4) :958-66.|[2]Zhao Y, et al. Carebastine, an H1-receptor antagonist, suppresses the expression of macrophage migration inhibitory factor. Clin Exp Dermatol. 2008 Nov;33 (6) :785-7.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
H1 Receptor

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