D-Cycloserine

• Description:

  D-Cycloserine is an antibiotic which targets sequential bacterial cell wall peptidoglycan biosynthesis enzymes. D-Cycloserine is a partial NMDA agonist that can improve cognitive functions. D-Cycloserine can be used for multidrug-resistant tuberculosis research[1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Antibiotic; Bacterial; iGluR

• Type:

  Natural Products

• Related Pathways:

  Anti-infection; Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection; Neurological Disease; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/D-Cycloserine.html

• Purity:

  99.97

• Solubility:

  DMSO : 1 mg/mL (warming) |H2O : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O=C1[C@H](N)CON1

• Molecular Formula:

  C3H6N2O2

• Molecular Weight:

  102.09

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Nitsche, M.A., et al., Consolidation of human motor cortical neuroplasticity by D-cycloserine. Neuropsychopharmacology, 2004. 29 (8) : p. 1573-8.|[2]Levin, E.D., et al., D-cycloserine selectively decreases nicotine self-administration in rats with low baseline levels of response. Pharmacol Biochem Behav, 2011. 98 (2) : p. 210-4.|[3]Sarah Batson, et al. Inhibition of D-Ala:D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine. Nat Commun. 2017 Dec 5;8 (1) :1939.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  Launched

• Isoform:

  NMDA Receptor

• CAS Number:

  [68-41-7]