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L-Cycloserine

CAT: 0804-HY-B1122-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B1122-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
L-Cycloserine ((S) -4-Amino-3-isoxazolidone) is an oral inhibitor of the enzyme gamma-aminobutyric acid (GABA) transaminase (GABA-t) and branched-chain transaminases in Mycobacterium tuberculosis. L-Cycloserine has anticonvulsant properties and inhibits the synthesis of neurotensin in mouse brains[1][2][3][4].
CAS Number
[339-72-0]
Product Name Alternative
(S) -Cycloserine; (S) -4-Amino-3-isoxazolidone
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
GABA Receptor; HIV
Type
Natural Products
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/L-Cycloserine.html
Concentration
10mM
Purity
99.50
Solubility
H2O : 200 mg/mL (ultrasonic)
Smiles
O=C1NOC[C@@H]1N
Molecular Formula
C3H6N2O2
Molecular Weight
102.09
Precautions
H302, H315, H319, H335
References & Citations
[1]Tathyana Mar Amorim Franco, et al. Mechanism-Based Inhibition of the Mycobacterium tuberculosis Branched-Chain Aminotransferase by d- and l-Cycloserine. ACS Chem Biol. 2017 May 19;12 (5) :1235-1244.|[2]S H Chung, et al. L-cycloserine: a potent anticonvulsant. Epilepsia. 1984 Jun;25 (3) :353-62.|[3]P Polc, et al. L-cycloserine: behavioural and biochemical effects after single and repeated administration to mice, rats and cats. Neuropharmacology. 1986 Apr;25 (4) :411-8.|[4]K S Sundaram, et al. Inhibition of cerebroside synthesis in the brains of mice treated with L-cycloserine. J Lipid Res. 1985 Apr;26 (4) :473-7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Launched

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