L-Cycloserine

• Description:

  L-Cycloserine ((S) -4-Amino-3-isoxazolidone) is an oral inhibitor of the enzyme gamma-aminobutyric acid (GABA) transaminase (GABA-t) and branched-chain transaminases in Mycobacterium tuberculosis. L-Cycloserine has anticonvulsant properties and inhibits the synthesis of neurotensin in mouse brains[1][2][3][4].

• Product Name Alternative:

  (S) -Cycloserine; (S) -4-Amino-3-isoxazolidone

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  GABA Receptor; HIV

• Type:

  Natural Products

• Related Pathways:

  Anti-infection; Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Neurological Disease; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/L-Cycloserine.html

• Concentration:

  10mM

• Purity:

  99.50

• Solubility:

  H2O : 200 mg/mL (ultrasonic)

• Smiles:

  O=C1NOC[C@@H]1N

• Molecular Formula:

  C3H6N2O2

• Molecular Weight:

  102.09

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Tathyana Mar Amorim Franco, et al. Mechanism-Based Inhibition of the Mycobacterium tuberculosis Branched-Chain Aminotransferase by d- and l-Cycloserine. ACS Chem Biol. 2017 May 19;12 (5) :1235-1244.|[2]S H Chung, et al. L-cycloserine: a potent anticonvulsant. Epilepsia. 1984 Jun;25 (3) :353-62.|[3]P Polc, et al. L-cycloserine: behavioural and biochemical effects after single and repeated administration to mice, rats and cats. Neuropharmacology. 1986 Apr;25 (4) :411-8.|[4]K S Sundaram, et al. Inhibition of cerebroside synthesis in the brains of mice treated with L-cycloserine. J Lipid Res. 1985 Apr;26 (4) :473-7.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  Launched

• CAS Number:

  [339-72-0]