DAC 5945

• Description :

  DAC 5945 is a potent muscarinic antagonist in the airways than in the heart, with pKi values of 8.3 and 7.52 for M1 and M2, respectively[1][2].

• CAS Number :

  [124065-13-0]

• UNSPSC :

  12352005

• Target :

  MAChR

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/dac-5945.html

• Smiles :

  OC(C1=CC=CC=C1)(C2CCCCC2)CN3CCN(C=N)CC3.[H]Cl

• Molecular Formula :

  C19H30ClN3O

• Molecular Weight :

  351.91

• References & Citations :

  [1]R E Howell, et al. Airway smooth muscle selectivity of the muscarinic antagonist DAC 5945 in vivo. Eur J Pharmacol. 1991 Apr 24;196 (3) :323-6.|[2]H N Doods, et al. Characterization of muscarinic receptors in guinea-pig uterus. Eur J Pharmacol. 1993 Dec 7;250 (2) :223-30.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported