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Recombinant Human CCL5/RANTES Protein

CAT: 0763-PDEH100742-01Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0763-PDEH100742-01Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV) . The processed form RANTES (3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES (4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES (1-68) and RANTES (3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils
Abbreviation
CCL5; RANTES
Synonyms
C-C motif chemokine 5; D17S136E; EoCP; Eosinophil chemotactic cytokine; SCYA5; SIS-delta; Small-inducible cytokine A5; T cell-specific protein P228; T-cell-specific protein RANTES; TCP228
UniProt
P13501
Accession Number
P13501
Expression System
E.coli
Tag
N-SUMO & C-His
Sequence
Ser24-Ser91
Field of Research
Immunology; Cardiovascular
Endotoxin
< 10 EU/mg of the protein as determined by the LAL method.
Purity
> 90% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
22.3 kDa
Observed Molecular Weight
25 kDa
Species
Human

UniProtKB · P13501

C-C motif chemokine 5

CCL5_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P13501
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CCL5
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
O43646, Q0QVW8, Q4ZGJ1, Q9NYA2, Q9UBG2, Q9UC99
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Biological process

ChemotaxisInflammatory response

Molecular function

Cytokine

PTM

Disulfide bondGlycoproteinOxidation

Cellular component

Secreted

Domain

Signal
Product Datasheet
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