Recombinant Human CCL22 Protein

• Background:

  May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. Binds to CCR4. Processed forms MDC (3-69), MDC (5-69) and MDC (7-69) seem not be active.

• Abbreviation:

  CCL22

• Synonyms:

  C-C motif chemokine 22; CC chemokine STCP-1; DC; MDC (1-69) ; Macrophage-derived chemokine; SCYA22; Small-inducible cytokine A22; Stimulated T-cell chemotactic protein 1

• UniProt:

  O00626

• Accession Number:

  O00626

• Expression System:

  E.coli

• Tag:

  N-His

• Sequence:

  Gly25-Gln93

• Field of Research:

  Immunology; Cardiovascular

• Endotoxin:

  < 10 EU/mg of the protein as determined by the LAL method.

• Purity:

  > 85% as determined by reducing SDS-PAGE.

• Bioactivity:

  Not validated for activity

• Reconstitution:

  It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

• Shipping Conditions:

  This product is provided as lyophilized powder which is shipped with ice packs.

• Storage Conditions:

  Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

• Calculated Molecular Weight:

  10.4 kDa

• Observed Molecular Weight:

  10 kDa

• Species:

  Human