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Perflubron

CAT: 0804-HY-B1724-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0804-HY-B1724-01Size:1 g
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Description
Perflubron (Perfluorooctyl bromide) is a contrast medium for magnetic resonance imaging and sonography. Perflubron inhibits chemokine expression and NF-κB activation. Perflubron can be emulsified with egg phospholipids (EYP) and shows exceptionally fast excretion characteristics. Perflubron has anti-inflammatory, antiviral and cytoprotective effects[1][2][3][4][5][6][7].
CAS Number
423-55-2
Product Name Alternative
Perfluorooctyl bromide; 1-Bromoperfluorooctane; PFOB
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
NF-κB; RSV
Type
Reference compound
Related Pathways
Anti-infection; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Infection; Inflammation/Immunology
Concentration
10mM
Purity
99.98
Solubility
DMSO : 16.67 mg/mL (ultrasonic)
Smiles
FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(Br)F
Molecular Formula
C8BrF17
Molecular Weight
498.96
Precautions
H302, H315, H319, H335
References & Citations
[1]Perflubron, From Wikipedia, the free encyclopedia|[2]Perflubron|[3]Woods CM, et al. Perflubron attenuates neutrophil adhesion to activated endothelial cells in vitro. Am J Physiol Lung Cell Mol Physiol. 2000 May;278 (5) :L1008-17.|[4]Babu PB, et al. Hyperoxia-induced changes in human airway epithelial cells: the protective effect of perflubron. Pediatr Crit Care Med. 2005 Mar;6 (2) :188-94.|[5]Kishioka C, et al. Perfluorooctyl bromide (perflubron) stimulates mucin secretion in the ferret trachea. Chest. 1999 Mar;115 (3) :823-8.|[6]Haeberle HA, et al. Perflubron reduces lung inflammation in respiratory syncytial virus infection by inhibiting chemokine expression and nuclear factor-kappa B activation. Am J Respir Crit Care Med. 2002 May 15;165 (10) :1433-8.|[7]Weiss DJ, et al. Perflubron enhances adenovirus-mediated gene expression in lungs of transgenic mice with chronic alveolar filling. Hum Gene Ther. 1999 Sep 20;10 (14) :2287-93.|[8]Weiss DJ, et al. Use of perflubron to enhance lung gene expression: safety and initial efficacy studies in non-human primates. Mol Ther. 2002 Jan;5 (1) :8-15.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

Chemical Information

Perfluorooctyl bromide

Perflubron is a haloalkane that is perfluorooctane in which a fluorine attached to one of the terminal carbons has been replaced by a bromine. It has a role as a radioopaque medium and a blood substitute. It is a perfluorinated compound, a haloalkane and an organobromine compound. It derives from a hydride of an octane.

CAS Number423-55-2
PubChem CID9873
IUPAC Name1-bromo-1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctane
Molecular FormulaC8BrF17
Molecular Weight498.96
XLogP6.9
Topological Polar Surface Area0
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count17
Rotatable Bond Count6
Heavy Atom Count26
Formal Charge0
Complexity527
SMILES
C(C(C(C(C(F)(F)Br)(F)F)(F)F)(F)F)(C(C(C(F)(F)F)(F)F)(F)F)(F)F
InChI
InChI=1S/C8BrF17/c9-7(22,23)5(18,19)3(14,15)1(10,11)2(12,13)4(16,17)6(20,21)8(24,25)26
InChIKey
WTWWXOGTJWMJHI-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Perfluorooctyl bromide
CAS: 423-55-2
CID: 9873
Formula: C8BrF17
MW: 498.96
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight498.96
XLogP36.9
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count17
Rotatable Bond Count6
Exact Mass497.89119
Monoisotopic Mass497.89119
Topological Polar Surface Area0 Ų
Heavy Atom Count26
Formal Charge0
Complexity527
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
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