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Perflubron

CAT: 0804-HY-B1724-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0804-HY-B1724-01Size:1 g
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Description
Perflubron (Perfluorooctyl bromide) is a contrast medium for magnetic resonance imaging and sonography. Perflubron inhibits chemokine expression and NF-κB activation. Perflubron can be emulsified with egg phospholipids (EYP) and shows exceptionally fast excretion characteristics. Perflubron has anti-inflammatory, antiviral and cytoprotective effects[1][2][3][4][5][6][7].
CAS Number
423-55-2
Product Name Alternative
Perfluorooctyl bromide; 1-Bromoperfluorooctane; PFOB
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
NF-κB; RSV
Type
Reference compound
Related Pathways
Anti-infection; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Infection; Inflammation/Immunology
Concentration
10mM
Purity
99.98
Solubility
DMSO : 16.67 mg/mL (ultrasonic)
Smiles
FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(Br)F
Molecular Formula
C8BrF17
Molecular Weight
498.96
Precautions
H302, H315, H319, H335
References & Citations
[1]Perflubron, From Wikipedia, the free encyclopedia|[2]Perflubron|[3]Woods CM, et al. Perflubron attenuates neutrophil adhesion to activated endothelial cells in vitro. Am J Physiol Lung Cell Mol Physiol. 2000 May;278 (5) :L1008-17.|[4]Babu PB, et al. Hyperoxia-induced changes in human airway epithelial cells: the protective effect of perflubron. Pediatr Crit Care Med. 2005 Mar;6 (2) :188-94.|[5]Kishioka C, et al. Perfluorooctyl bromide (perflubron) stimulates mucin secretion in the ferret trachea. Chest. 1999 Mar;115 (3) :823-8.|[6]Haeberle HA, et al. Perflubron reduces lung inflammation in respiratory syncytial virus infection by inhibiting chemokine expression and nuclear factor-kappa B activation. Am J Respir Crit Care Med. 2002 May 15;165 (10) :1433-8.|[7]Weiss DJ, et al. Perflubron enhances adenovirus-mediated gene expression in lungs of transgenic mice with chronic alveolar filling. Hum Gene Ther. 1999 Sep 20;10 (14) :2287-93.|[8]Weiss DJ, et al. Use of perflubron to enhance lung gene expression: safety and initial efficacy studies in non-human primates. Mol Ther. 2002 Jan;5 (1) :8-15.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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CatalogName
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