Perflubron

• Description:

  Perflubron (Perfluorooctyl bromide) is a contrast medium for magnetic resonance imaging and sonography. Perflubron inhibits chemokine expression and NF-κB activation. Perflubron can be emulsified with egg phospholipids (EYP) and shows exceptionally fast excretion characteristics. Perflubron has anti-inflammatory, antiviral and cytoprotective effects[1][2][3][4][5][6][7].

• Product Name Alternative:

  Perfluorooctyl bromide; 1-Bromoperfluorooctane; PFOB

• UNSPSC:

  12352211

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  NF-κB; RSV

• Type:

  Reference compound

• Related Pathways:

  Anti-infection; NF-κB

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Infection; Inflammation/Immunology

• Concentration:

  10mM

• Purity:

  99.98

• Solubility:

  DMSO : 16.67 mg/mL (ultrasonic)

• Smiles:

  FC (F) (F) C (F) (F) C (F) (F) C (F) (F) C (F) (F) C (F) (F) C (F) (F) C (F) (Br) F

• Molecular Formula:

  C8BrF17

• Molecular Weight:

  498.96

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Perflubron, From Wikipedia, the free encyclopedia|[2]Perflubron|[3]Woods CM, et al. Perflubron attenuates neutrophil adhesion to activated endothelial cells in vitro. Am J Physiol Lung Cell Mol Physiol. 2000 May;278 (5) :L1008-17.|[4]Babu PB, et al. Hyperoxia-induced changes in human airway epithelial cells: the protective effect of perflubron. Pediatr Crit Care Med. 2005 Mar;6 (2) :188-94.|[5]Kishioka C, et al. Perfluorooctyl bromide (perflubron) stimulates mucin secretion in the ferret trachea. Chest. 1999 Mar;115 (3) :823-8.|[6]Haeberle HA, et al. Perflubron reduces lung inflammation in respiratory syncytial virus infection by inhibiting chemokine expression and nuclear factor-kappa B activation. Am J Respir Crit Care Med. 2002 May 15;165 (10) :1433-8.|[7]Weiss DJ, et al. Perflubron enhances adenovirus-mediated gene expression in lungs of transgenic mice with chronic alveolar filling. Hum Gene Ther. 1999 Sep 20;10 (14) :2287-93.|[8]Weiss DJ, et al. Use of perflubron to enhance lung gene expression: safety and initial efficacy studies in non-human primates. Mol Ther. 2002 Jan;5 (1) :8-15.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• CAS Number:

  423-55-2