HS024 (TFA)

• UNSPSC Description:

  HS024 is a selective MC4 receptor antagonist, with Kis of 0.29, 3.29, 5.45, 18.6 nM for MC4, MC5, MC3, and MC1, respectively. HS024 increase food intake[1].

• Target Antigen:

  Melanocortin Receptor

• Type:

  Peptides

• Related Pathways:

  GPCR/G Protein;Neuronal Signaling

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/hs024-tfa.html

• Purity:

  99.80

• Solubility:

  H2O : 50 mg/mL (ultrasonic)

• Smiles:

  CCCC[C@@H]1NC([C@@H](NC(C)=O)CSSC[C@@H](C(N)=O)NC(CNC([C@@H](NC([C@@H](NC([C@H](NC([C@@H](NC([C@@H](NC1=O)CCCNC(N)=N)=O)CC2=C[N]C=N2)=O)CC3=CC4=C(C=CC=C4)C=C3)=O)CCCNC(N)=N)=O)CC5C=NC6=C5C=CC=C6)=O)=O)=O.O=C(O)C(F)(F)F

• Molecular Weight:

  1380.52

• References & Citations:

  [1]Kask A, et al. Discovery of a novel superpotent and selective melanocortin-4 receptor antagonist (HS024): evaluation in vitro and in vivo. Endocrinology. 1998;139(12):5006-5014.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Clinical Information:

  No Development Reported