AMRI-59

CAT: 0804-HY-111125-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-111125-01Size:1 mg
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Description
AMRI-59 is a potent inhibitor of PrxI used for parasitic infections. AMRI-59 can increase cellular ROS, leading to activation of signaling pathways mediated by mitochondria and apoptosis signal-regulated kinase 1, thereby leading to apoptosis in A549 human lung adenocarcinoma. AMRI-59 exhibits significant antitumor activity without apparent acute toxicity[1].
CAS Number
[923515-92-8]
UNSPSC
12352005
Target
Apoptosis; Parasite; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/amri-59.html
Solubility
10 mM in DMSO
Smiles
O=C(N1CCC(CC2=CC=C(N3C=CC=C3)C=C2)CC1)NC4=CC=CC(C(C)=O)=C4
Molecular Formula
C25H27N3O2
Molecular Weight
401.50
References & Citations
[1]Yang YJ, et al. Effective Killing of Cancer Cells Through ROS-Mediated Mechanisms by AMRI-59 Targeting Peroxiredoxin I. Antioxid Redox Signal. 2016 Mar 10;24 (8) :453-69.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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