PM-81I

• Description :

  PM-81I is a potent STAT6 inhibitor (targeting the SH2 structural domain) that effectively reduces STAT6 phosphorylation levels. PM-81I can be used in studies of allergic lung disease, allergic rhinitis, chronic obstructive pulmonary disease or cancer[1].

• UNSPSC :

  12352005

• Target :

  STAT

• Type :

  Reference compound

• Related Pathways :

  JAK/STAT Signaling; Stem Cell/Wnt

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/pm-81i.html

• Purity :

  99.91

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(N1CC2=CC=CC=C2CC1)[C@H]3N(CCC3)C([C@H](C(C)(C)C)NC(/C=C(C4=CC=C(C=C4)C(F)(F)P(OCOC(C(C)(C)C)=O)(OCOC(C(C)(C)C)=O)=O)\C)=O)=O

• Molecular Formula :

  C43H58F2N3O10P

• Molecular Weight :

  845.91

• References & Citations :

  [1]John S, et al. Stat6 inhibitors. Patent WO2014182928A2.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1637532-83-2]