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3-Deoxyglucosone

CAT: 0804-HY-N7426-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N7426-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
3-Deoxyglucosone (3-Deoxy-D-glucosone) is a reactive intermediate of the Maillard reaction and the polyol pathway. 3-Deoxyglucosone rapidly reacts with protein amino groups to form advanced glycation end products (AGEs), such as imidazolone, it is the most specific AGE for 3-DG. 3-Deoxyglucosone synergizes with low glucose to potentiate GLP-1 secretion and is considered as a biomarker for diabetes[1][2][3].
CAS Number
4084-27-9
Product Name Alternative
3-Deoxy-D-glucosone
UNSPSC
12352211
Hazard Statement
H315, H319, H335
Target
GLP Receptor
Type
Natural Products
Related Pathways
GPCR/G Protein
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/3-deoxyglucosone.html
Purity
95.0
Solubility
10 mM in DMSO
Smiles
OC[C@@H](O)[C@@H](O)CC(C=O)=O
Molecular Formula
C6H10O5
Molecular Weight
162.14
Precautions
H315, H319, H335
References & Citations
[1]Song X, et al. 3-Deoxyglucosone Induces Glucagon-Like Peptide-1 Secretion from STC-1 Cells via Upregulating Sweet Taste Receptor Expression under Basal Conditions.Int J Endocrinol. 2019 Oct 23;2019:4959646.|[2] Wang F, et al. Acute Reduction of Incretin Effect and Glucose Intolerance in Rats by Single Intragastric Administration of 3-deoxyglucosone. Exp Clin Endocrinol Diabetes. 2017 Jan;125 (1) :4-11.|[3]Zhang L, et al. Accumulation of intestinal tissue 3-deoxyglucosone attenuated GLP-1 secretion and its insulinotropic effect in rats. Diabetol Metab Syndr. 2016 Nov 29;8:78.|[4]Niwa T, et al. 3-Deoxyglucosone: metabolism, analysis, biological activity, and clinical implication.J Chromatogr B Biomed Sci Appl. 1999 Aug 6;731 (1) :23-36.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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