Citalopram (hydrobromide)

• UNSPSC Description:

  Citalopram hydrobromide is a selective serotonin reuptake inhibitor (SSRI). Citalopram hydrobromide inhibits 5-HT uptake into synaptosomes with an IC50 of 1.8 nM. Citalopram hydrobromideinhibits the 5-HT uptake in rabbit blood platelets with an IC50 of 14 nM. Antidepressant effect[1].

• Target Antigen:

  Autophagy; Serotonin Transporter

• Type:

  Reference compound

• Related Pathways:

  Autophagy;Neuronal Signaling

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Neurological Disease; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Citalopram-hydrobromide.html

• Purity:

  99.93

• Solubility:

  DMSO : ≥ 38 mg/mL|H2O : 10 mg/mL (ultrasonic)

• Smiles:

  N#CC1=CC2=C(C(C3=CC=C(F)C=C3)(CCCN(C)C)OC2)C=C1.[H]Br

• Molecular Weight:

  405.30

• References & Citations:

  [1]J Hyttel. Citalopram--pharmacological profile of a specific serotonin uptake inhibitor with antidepressant activity. Prog Neuropsychopharmacol Biol Psychiatry. 1982;6(3):277-95.|[2]Laurent Sakka, et al. Assessment of citalopram and escitalopram on neuroblastoma cell lines. Cell toxicity and gene modulation. Oncotarget. 2017 Jun 27;8(26):42789-42807.|[3]F Pollier, et al. Serotonin reuptake inhibition by citalopram in rat strains differing for their emotionality. Neuropsychopharmacology. 2000 Jan;22(1):64-76.Eur J Pharmacol. 2018 Sep 27;841:57-66.|J Clin Psychopharmacol. 2021 Jun 11.|Neurochem Int. 2019 Dec;131:104552.|Pharmacol Res Perspect. 2020 Apr;8(2):e00575.|Research Square Preprint. 2021 Feb.|Comput Struct Biotechnol J. 2023 Jul 7, 21, 3490-3502.|Orebro University. 2024.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  Launched

• CAS Number:

  59729-32-7