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Citalopram (hydrobromide)

CAT: 0804-HY-B1287-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1287-01Size:5 mg
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Description
Citalopram hydrobromide is a selective serotonin reuptake inhibitor (SSRI) . Citalopram hydrobromide inhibits 5-HT uptake into synaptosomes with an IC50 of 1.8 nM. Citalopram hydrobromideinhibits the 5-HT uptake in rabbit blood platelets with an IC50 of 14 nM. Antidepressant effect[1].
CAS Number
59729-32-7
Product Name Alternative
(±) -Citalopram hydrobromide; Lu 10-171
UNSPSC
12352005
Hazard Statement
H302
Target
Autophagy; Serotonin Transporter
Type
Reference compound
Related Pathways
Autophagy; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/Citalopram-hydrobromide.html
Purity
99.87
Solubility
DMSO : ≥ 38 mg/mL|H2O : 10 mg/mL (ultrasonic)
Smiles
N#CC1=CC2=C(C(C3=CC=C(F)C=C3)(CCCN(C)C)OC2)C=C1.[H]Br
Molecular Formula
C20H22BrFN2O
Molecular Weight
405.30
Precautions
H302
References & Citations
[1]J Hyttel. Citalopram--pharmacological profile of a specific serotonin uptake inhibitor with antidepressant activity. Prog Neuropsychopharmacol Biol Psychiatry. 1982;6 (3) :277-95.|[2]Laurent Sakka, et al. Assessment of citalopram and escitalopram on neuroblastoma cell lines. Cell toxicity and gene modulation. Oncotarget. 2017 Jun 27;8 (26) :42789-42807.|[3]F Pollier, et al. Serotonin reuptake inhibition by citalopram in rat strains differing for their emotionality. Neuropsychopharmacology. 2000 Jan;22 (1) :64-76.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Citation 01
ACS Chem Neurosci. 2025 Jun 18;16 (12) :2312-2321.|Eur J Pharmacol. 2018 Dec 15:841:57-66.|J Clin Psychopharmacol. 2021 Sep-Oct;41 (5) :525-533.|Neurochem Int. 2019 Dec;131:104552.|Pharmacol Res Perspect. 2020 Apr;8 (2) :e00575.|Research Square Preprint. 2021 Feb.|Comput Struct Biotechnol J. 2023 Jul 7:21:3490-3502.|Orebro University. 2024.

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