Mivebresib

Chemical Information
Mivebresib is a small molecule drug. The usage of the INN stem '-bresib' in the name indicates that Mivebresib is a inhibitor of the bromodomain and extra-terminal motif (BET) family of bromodomain (BRD) protein, antineoplastic. Mivebresib is under investigation in clinical trial NCT04480086 (Safety and Tolerability Study of Mivebresib Tablet Alone or in Combination With Ruxolitinib Tablet or Navitoclax Tablet in Adult Participants With Myelofibrosis). Mivebresib has a monoisotopic molecular weight of 459.11 Da.
| CAS Number | 1445993-26-9 |
| PubChem CID | 71600087 |
| IUPAC Name | N-[4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl]ethanesulfonamide |
| Molecular Formula | C22H19F2N3O4S |
| Molecular Weight | 459.5 |
| XLogP | 2.9 |
| Topological Polar Surface Area | 99.9 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 7 |
| Rotatable Bond Count | 6 |
| Heavy Atom Count | 32 |
| Formal Charge | 0 |
| Complexity | 834 |
| Property | Value |
|---|---|
| Molecular Weight | 459.5 |
| XLogP3 | 2.9 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 7 |
| Rotatable Bond Count | 6 |
| Exact Mass | 459.10643359 |
| Monoisotopic Mass | 459.10643359 |
| Topological Polar Surface Area | 99.9 Ų |
| Heavy Atom Count | 32 |
| Formal Charge | 0 |
| Complexity | 834 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
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SKU: A0855-98-APC|Size: 200 µL

ACVR2A, NT (Activin Receptor Type-2A, Activin Receptor Type IIA, ACTR-IIA, ACTRIIA, ACVR2) (FITC) discontinued
SKU: A0855-98-FITC|Size: 200 µL

ACVR2A, NT (Activin Receptor Type-2A, Activin Receptor Type IIA, ACTR-IIA, ACTRIIA, ACVR2) (HRP) discontinued
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