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Mivebresib

CAT: 0013-GTR19170947-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19170947-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mivebresib (ABBV-075) is a potent and selective BET bromodomain inhibitor that displaces BET proteins from acetylated chromatin, suppressing oncogenic transcription factors like MYC and TMPRSS2-ETS fusions. It demonstrates robust antitumor activity in preclinical models of hematologic malignancies and solid tumors, supporting its investigation in cancer research.
CAS Number
1445993-26-9
Product Name Alternative
Inhibitor, EpigeneticReaderDomain, Epigenetic Reader Domain, inhibit, Mivebresib, ABBV 075, ABBV-075, ABBV075, Apoptosis, BET
Field of Research
Cell Biology, Epigenetics & Chromatin
Purity
97.17% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.18 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:250 mg/mL (544.11 mM)
Smiles
O (C1=C (C=2C3=C (C (=O) N (C) C2) NC=C3) C=C (NS (CC) (=O) =O) C=C1) C4=C (F) C=C (F) C=C4
Molecular Formula
C22H19F2N3O4S
Molecular Weight
459.47
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Mivebresib

Mivebresib is a small molecule drug. The usage of the INN stem '-bresib' in the name indicates that Mivebresib is a inhibitor of the bromodomain and extra-terminal motif (BET) family of bromodomain (BRD) protein, antineoplastic. Mivebresib is under investigation in clinical trial NCT04480086 (Safety and Tolerability Study of Mivebresib Tablet Alone or in Combination With Ruxolitinib Tablet or Navitoclax Tablet in Adult Participants With Myelofibrosis). Mivebresib has a monoisotopic molecular weight of 459.11 Da.

CAS Number1445993-26-9
PubChem CID71600087
IUPAC NameN-[4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl]ethanesulfonamide
Molecular FormulaC22H19F2N3O4S
Molecular Weight459.5
XLogP2.9
Topological Polar Surface Area99.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count6
Heavy Atom Count32
Formal Charge0
Complexity834
SMILES
CCS(=O)(=O)NC1=CC(=C(C=C1)OC2=C(C=C(C=C2)F)F)C3=CN(C(=O)C4=C3C=CN4)C
InChI
InChI=1S/C22H19F2N3O4S/c1-3-32(29,30)26-14-5-7-19(31-20-6-4-13(23)10-18(20)24)16(11-14)17-12-27(2)22(28)21-15(17)8-9-25-21/h4-12,25-26H,3H2,1-2H3
InChIKey
RDONXGFGWSSFMY-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Mivebresib
CAS: 1445993-26-9
CID: 71600087
Formula: C22H19F2N3O4S
MW: 459.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight459.5
XLogP32.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count6
Exact Mass459.10643359
Monoisotopic Mass459.10643359
Topological Polar Surface Area99.9 Ų
Heavy Atom Count32
Formal Charge0
Complexity834
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
B1564-5Mivebresib
HY-169980Mivebresib-alkyne
HY-100015R-01Mivebresib (Standard)
MBS3842201-01Mivebresib (ABBV-075)
A17226-50Mivebresib (ABBV-075) 50mg

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