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Foxy-5

CAT: 0804-HY-P1416-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P1416-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Foxy-5, a WNT5A agonist, is a mimicking peptide of WNT5A which is a non-canonical member of the Wnt family. Foxy-5 triggers cytosolic free calcium signaling without affecting β-catenin activation and it impairs the migration and invasion of epithelial cancer cells. Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model[1][2][3].
CAS Number
881188-51-8
UNSPSC
12352209
Target
Wnt
Type
Peptides
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/foxy-5.html
Purity
99.56
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C([C@H](CS)NC(CNC([C@H](CC(O)=O)NC([C@@H](NC=O)CCSC)=O)=O)=O)N[C@@H](CCC(O)=O)C(N[C@H](C(O)=O)CC(C)C)=O
Molecular Formula
C26H42N6O12S2
Molecular Weight
694.77
References & Citations
[1]Säfholm A, et al. The Wnt-5a-derived hexapeptide Foxy-5 inhibits breast cancer metastasis in vivo by targeting cell motility. Clin Cancer Res. 2008 Oct 15;14 (20) :6556-63.|[2]Osman J, et al. The WNT5A Agonist Foxy5 Reduces the Number of Colonic Cancer Stem Cells in a Xenograft Mouse Model of Human Colonic Cancer. Anticancer Res. 2019 Apr;39 (4) :1719-1728.|[3]Canesin G, et al. Treatment with the WNT5A-mimicking peptide Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model. PLoS One. 2017 Sep 8;12 (9) :e0184418.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Scientific Category
Peptides
Clinical Information
Phase 2
Isoform
Wnt5
Citation 01
Int J Oral Sci. 2024 Feb 19;16 (1) :15.|iScience. 2024 Dec 1;27 (12) :111517.|Phytomedicine. 2025 Feb 10:139:156491.|J Neuroinflammation. 2024 Mar 26;21 (1) :75.|Patent. US20230130144A1.|Pathol Res Pract. 2024 May 26:259:155369.

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