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PQR626

CAT: 0804-HY-136660-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-136660-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PQR626, a rapamycin derivative, is a potent, selective, orally active, and brain-penetrant mTOR inhibitor, with an IC50 and Ki of 5 nM and 3.6 nM, respectively. PQR626 can be can be used for the research of neurological disorders[1][2].
CAS Number
1927857-98-4
UNSPSC
12352005
Target
MTOR
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mtor-inhibitor-7.html
Purity
98.05
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NC1=NC=C(C2=NC(N3[C@H](C)COC[C@@H]3C)=NC(N4[C@H](C)COCC4)=N2)C(C(F)F)=C1
Molecular Formula
C20H27F2N7O2
Molecular Weight
435.47
References & Citations
[1]Denise RAGEOT, et al. Treatment of neurological disorders. WO2017198346A1.|[2]Chiara Borsari, et al. 4- (Difluoromethyl) -5- (4- ((3 R,5 S) -3,5-dimethylmorpholino) -6- ((R) -3-methylmorpholino) -1,3,5-triazin-2-yl) pyridin-2-amine (PQR626), a Potent, Orally Available, and Brain-Penetrant mTOR Inhibitor for the Treatment of Neurological Disorders. J Med Chem. 2020 Nov 25;63 (22) :13595-13617.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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