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PQR620 (Standard)

CAT: 0804-HY-100026RSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-100026RSize:1 Each
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Description
PQR620 (Standard) is the analytical standard of PQR620. This product is intended for research and analytical applications. PQR620 is an orally bioavailable and selective brain penetrant inhibitor of mTORC1/2[1].
CAS Number
1927857-56-4
Target
MTOR; Reference Standards
Related Pathways
Others; PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
[H][C@]1(CC[C@]([H])2COC1)N2C3=NC(N4[C@]5([H])CC[C@]([H])4COC5)=NC(C6=CN=C(N)C=C6C(F)F)=N3
Molecular Formula
C21H25F2N7O2
Molecular Weight
445.47
References & Citations
[1]Florent Beaufils, et al. Abstract 1336: Structure-activity relationship studies, synthesis, and biological evaluation of PQR620, a highly potent and selective mTORC1/2 inhibitor. Cancer Research; 2016 Apr 16-20.|[2]Chiara Tarantelli, et al. Targeting the PI3K/mTOR Pathway in Lymphoma with PQR309 and PQR620: Single Agent Activity and Synergism with the BCL2 Inhibitor Venetoclax. Blood 2016 128:3017.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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Alternative Products

CatalogName
T5472-01PQR620
A20400-5PQR620 5mg
A20400-50PQR620 50mg
A20400-25PQR620 25mg
A20400-1PQR620 1mg
A20400-200PQR620 200mg
A20400-100PQR620 100mg
A20400-10PQR620 10mg
A20400-10mM-DPQR620 10mM * 1mL in DMSO
abx098968-01Standard

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