Epsilon-V1-2

Epsilon-V1-2

• CAS Number: 182683-50-7
• UNSPSC Description: Epsilon-V1-2 (ε-V1-2), a PKCε-derived peptide, is a selective PKCε inhibitor. Epsilon-V1-2 inhibits the translocationof PKCε, but not α-, β-, and δPKC[1].
• Target Antigen: PKC
• Type: Peptides
• Related Pathways: Epigenetics;TGF-beta/Smad
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/epsilon-v1-2.html
• Purity: 97.04
• Solubility: H2O : 100 mg/mL (ultrasonic)
• Smiles: O=C(N[C@@H](C)C(N[C@@H](C(C)C)C(N[C@@H](CO)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N1[C@@H](CCC1)C(N[C@@H]([C@H](O)C)C(O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCC(O)=O)N
• Molecular Weight: 843.96
• References & Citations: [1]M Yedovitzky, et al. Translocation inhibitors define specificity of protein kinase C isoenzymes in pancreatic beta-cells. J Biol Chem. 1997 Jan 17;272(3):1417-20.|[2]Yuahn-Sieh Huang, et al. Mechanism of oleic acid-induced gap junctional disassembly in rat cardiomyocytes. J Mol Cell Cardiol. 2004 Sep;37(3):755-66.|[3]Tomoyoshi Koyanagi, et al. Pharmacological inhibition of epsilon PKC suppresses chronic inflammation in murine cardiac transplantation model. J Mol Cell Cardiol. 2007 Oct;43(4):517-22.
• Shipping Conditions: Blue Ice
• Storage Conditions: -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported