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DOPE (Excipient)

CAT: 0804-HY-112005ASize: InquireDry Ice: NoHazardous: No
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CAT#:0804-HY-112005ASize:Inquire
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CAS Number
4004-05-1
UNSPSC Description
DOPE Excipient (dioleoylphosphatidylethanolamine) is a neutral helper lipid for cationic liposome and combines with cationic phospholipids to improve transfection efficiency of naked siRNA[1].
Target Antigen
Endogenous Metabolite; Liposome
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/dope-excipient.html
Smiles
O=P(OC[C@H](OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O)(OCCN)O
Molecular Weight
744.03
References & Citations
[1]Uemura Y, et al. The efficiency of lipid nanoparticles with an original cationic lipid as a siRNA delivery system for macrophages and dendritic cells.Pharm Dev Technol. 2019 Mar;24(3):263-268.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported

Chemical Information

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine

1,2-di-[(9Z)-octadecenoyl]-sn-glycero-3-phosphoethanolamine is a 1,2-diacyl-sn-glycero-3-phosphoethanolamine in which the acyl substituent both at positions 1 and 2 is specified as (9Z)-octadecenoyl respectively. It has a role as a mouse metabolite. It is functionally related to an oleic acid.

CAS Number4004-05-1
PubChem CID9546757
IUPAC Name[(2R)-3-[2-aminoethoxy(hydroxy)phosphoryl]oxy-2-[(Z)-octadec-9-enoyl]oxypropyl] (Z)-octadec-9-enoate
Molecular FormulaC41H78NO8P
Molecular Weight744.0
XLogP10.6
Topological Polar Surface Area134
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count41
Heavy Atom Count51
Formal Charge0
Complexity897
SMILES
CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@H](COP(=O)(O)OCCN)OC(=O)CCCCCCC/C=C\CCCCCCCC
InChI
InChI=1S/C41H78NO8P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-40(43)47-37-39(38-49-51(45,46)48-36-35-42)50-41(44)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h17-20,39H,3-16,21-38,42H2,1-2H3,(H,45,46)/b19-17-,20-18-/t39-/m1/s1
InChIKey
MWRBNPKJOOWZPW-NYVOMTAGSA-N
Chemical Structure
2D Structure
2D structure of 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine
CAS: 4004-05-1
CID: 9546757
Formula: C41H78NO8P
MW: 744.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight744.0
XLogP310.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count41
Exact Mass743.54650544
Monoisotopic Mass743.54650544
Topological Polar Surface Area134 Ų
Heavy Atom Count51
Formal Charge0
Complexity897
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count2
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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