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SM-102 (Excipient)

CAT: 0804-HY-134541ASize: InquireDry Ice: NoHazardous: No
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2089251-47-6
UNSPSC Description
SM-102 Excipient is an amino cationic lipid useful in the formation of lipid nanoparticles (LNPs). SM-102 Excipient has higher transfection efficiency. SM-102 Excipient plays an important role in the effectiveness of lipid nanoparticles (LNPs) in delivering mRNA therapeutics and vaccines[1][2].
Target Antigen
Liposome
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/sm-102-excipient.html
Smiles
O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCO)CCCCCC(OCCCCCCCCCCC)=O
Molecular Weight
710.17
References & Citations
[1]Staci Sabnis, et al. A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates. Mol Ther. 2018 Jun 6;26(6):1509-1519.|[2]Escalona-Rayo O, et al. In vitro and in vivo evaluation of clinically-approved ionizable cationic lipids shows divergent results between mRNA transfection and vaccine efficacy. Biomed Pharmacother. 2023 Sep;165:115065.|[3]Cho HY, et al. Effective Perturbations on the Amplitude and Hysteresis of Erg-Mediated Potassium Current Caused by 1-Octylnonyl 8-[(2-hydroxyethyl)[6-oxo-6(undecyloxy)hexyl]amino]-octanoate (SM-102), a Cationic Lipid. Biomedicines. 2021 Oct 1;9(10):1367.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported

Chemical Information

SM-102
CAS Number2089251-47-6
PubChem CID126697616
IUPAC Nameheptadecan-9-yl 8-[2-hydroxyethyl-(6-oxo-6-undecoxyhexyl)amino]octanoate
Molecular FormulaC44H87NO5
Molecular Weight710.2
XLogP15.5
Topological Polar Surface Area76.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count43
Heavy Atom Count50
Formal Charge0
Complexity686
SMILES
CCCCCCCCCCCOC(=O)CCCCCN(CCCCCCCC(=O)OC(CCCCCCCC)CCCCCCCC)CCO
InChI
InChI=1S/C44H87NO5/c1-4-7-10-13-16-17-18-24-32-41-49-43(47)35-29-25-31-38-45(39-40-46)37-30-23-19-22-28-36-44(48)50-42(33-26-20-14-11-8-5-2)34-27-21-15-12-9-6-3/h42,46H,4-41H2,1-3H3
InChIKey
BGNVBNJYBVCBJH-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of SM-102
CAS: 2089251-47-6
CID: 126697616
Formula: C44H87NO5
MW: 710.2
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight710.2
XLogP315.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count43
Exact Mass709.65842488
Monoisotopic Mass709.65842488
Topological Polar Surface Area76.1 Ų
Heavy Atom Count50
Formal Charge0
Complexity686
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
464358SM-102

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