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Entecavir-d2

CAT: 0804-HY-13623SSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-13623SSize:1 Each
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Description
Entecavir-d2 is the deuterium labeled Entecavir. Entecavir (SQ 34676; BMS 200475) is a potent and selective inhibitor of HBV, with an EC50 of 3.75 nM in HepG2 cell.
Product Name Alternative
BMS200475-d2; SQ34676-d2
UNSPSC
12352005
Target
HBV; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Others
Field of Research
Infection
Solubility
10 mM in DMSO
Smiles
NC(N1)=NC(C2=C1N([C@@H](C[C@H](O)[C@H]/3CO)C3=C([2H])\[2H])C=N2)=O
Molecular Formula
C12H13D2N5O3
Molecular Weight
279.29
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Innaimo SF, et al. Identification of?BMS-200475?as a potent and selective inhibitor of hepatitis B virus. Antimicrob Agents Chemother. 1997 Jul;41 (7) :1444-9.|[3]Rivkin A, et al. A review of entecavir in the treatment of chronic hepatitis B infection. Curr Med Res Opin.?2005 Nov;21 (11) :1845-57.|[4]Genovesi EV, et al. Efficacy of the carbocyclic 2'-deoxyguanosine nucleoside?BMS-200475?in the woodchuck model of hepatitis B virus infection. Antimicrob Agents Chemother.?1998 Dec;42 (12) :3209-18.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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